E Mixolydian Scale: Notes, Chords, and How to Play It

E Mixolydian is the ultimate open-string blues key on guitar. Built on the 5th degree of A major, it shares those same notes but treats E as home. With both the low and high E strings available as open drones, this mode practically plays itself on guitar. The dominant 7th tonic (E7) is the foundation of countless blues songs, and E Mixolydian is the scale that gives those songs their melodic vocabulary.

What Makes Mixolydian Different from Major?

The Mixolydian mode is almost identical to the major scale. The only difference is the flatted seventh degree — the note one whole step below the root instead of a half step. In E Mixolydian, this means D natural rather than D♯.

This ♭7 removes the leading tone — that half-step pull from the 7th degree up to the root that gives the major scale its strong sense of resolution. Without it, Mixolydian sounds more open, relaxed, and bluesy. The tonic chord is naturally a dominant 7th (E7) rather than a major 7th, which is exactly why Mixolydian is the go-to scale for playing over dominant 7th chords in jazz and blues.

For a broader overview of how modes work, see Modes Explained: Dorian to Locrian.

Notes of the E Mixolydian Scale

The E Mixolydian scale contains seven notes:

E – F♯ – G♯ – A – B – C♯ – D

These are the same notes as A major, but starting and resolving on E. The scale follows the Mixolydian interval pattern — W – W – H – W – W – H – W.

The half steps fall between G♯–A (degrees 3–4) and C♯–D (degrees 6–7). Compare this to E major, where the half steps fall between G♯–A and D♯–E. The only change is that final interval: D replaces D♯.

Parent Major Scale

E Mixolydian is the 5th mode of A major. This means it uses exactly the same notes as A major but with E as the tonal centre.

To find the parent major scale for any Mixolydian mode, go down a perfect 5th (or up a perfect 4th) from the root.

Comparison with E Major

Since Mixolydian differs from major by just one note, a direct comparison is the clearest way to understand the mode:

That single change — D♯ to D — transforms the sound. The major scale pulls strongly towards resolution; the Mixolydian mode sits comfortably without that tension.

E Mixolydian on Piano

E Mixolydian has three sharps: F♯, C♯, and G♯. This is the same key signature as A major, so if you are comfortable with A major on piano, you already know where to put your fingers — just start on E.

Right hand fingering (ascending): 1 – 2 – 3 – 1 – 2 – 3 – 4 – 5 (thumb crosses under after G♯, then fingers walk up to E)

Left hand fingering (ascending): 5 – 4 – 3 – 2 – 1 – 3 – 2 – 1 (after the thumb plays B, the third finger crosses over to C♯)

Hold an E7 chord with the left hand while running the scale with the right to reinforce the Mixolydian sound and train your ear to hear E as home.

E Mixolydian on Guitar

E Mixolydian is arguably the most natural mode on guitar. Both the low 6th string and high 1st string are E, giving you open-string roots at both ends of the instrument.

Open position (low to high):

Notice how the open D string (4th string) is a scale tone — it is the ♭7, the defining Mixolydian interval. This makes the ♭7 immediately accessible on guitar without stretching.

Use the guitar fretboard view in the Interactive Chord Finder to see all positions at once.

Diatonic Chords in E Mixolydian

Stacking thirds on each scale degree produces these seven triads:

The ♭VII chord (D major in E Mixolydian) is the characteristic chord of the mode. On guitar, the open D chord shape makes this a very accessible sound.

For more on how diatonic chords are constructed, see Diatonic Chords: A Beginner’s Guide.

Seventh Chords

Adding a fourth note to each triad creates seventh chords:

The tonic chord is a dominant 7th (E7) — one of the most fundamental chords in blues and rock guitar. The open E7 shape is often the first chord blues guitarists learn.

For more on seventh chords, see Seventh Chords: The Complete Guide.

Common Chord Progressions in E Mixolydian

Mixolydian progressions tend to be simpler and more riff-driven than major key progressions.

The I – ♭VII movement (E – D) is a staple of rock guitar — two of the easiest open chords on the instrument, producing the most satisfying Mixolydian sound.

For a deeper dive into how progressions work, see Chord Progressions Every Musician Should Know.

Songs That Use E Mixolydian

E Mixolydian appears in many iconic songs:

• “Crossroads” — Cream (E7 blues)
• “Johnny B. Goode” — Chuck Berry
• “Born on the Bayou” — Creedence Clearwater Revival
• “Honky Tonk Women” — The Rolling Stones
• “Cissy Strut” — The Meters
• “Chameleon” — Herbie Hancock (E7 funk vamp)

Listen for the ♭7 note (D natural) in the melody or the ♭VII chord (D major) in the harmony — these are the tell-tale signs of Mixolydian rather than plain major.

Related Scales and Modes

E Mixolydian belongs to the A major family. All seven modes share the same notes:

Practice Tips

Emphasise the ♭7. Play E major ascending, then play E Mixolydian. The only difference is D vs D♯ — train your ear to hear that subtle but powerful shift.

Vamp on I – ♭VII. Alternate between E and D chords while improvising with the scale. On guitar, these are both easy open chords.

Play a blues in E. The 12-bar blues in E (E7 – A7 – B7) is the most common blues form on guitar. Use E Mixolydian over the E7 sections.

Use open strings as drones. Let the open low E and high E strings ring while playing scale patterns on the middle strings. This anchors the Mixolydian tonality.

Try hammer-ons and pull-offs. On guitar, the Mixolydian scale in open position is perfect for hammer-on and pull-off exercises using open strings.

Try It Yourself

Open the Interactive Chord Finder, select E as the root and Mixolydian as the scale. You will see every note highlighted on the piano keyboard or guitar fretboard, the step pattern visualised as intervals, and all diatonic chords laid out in a table — ready to play and explore.

For the complete list of scales in every key, see Scales for Piano and Guitar: The Complete Reference Guide.